• Stem cell therapies are becoming a basis for regenerative medicine, aiding in cellular based research, development of new organs and tissues, and a treatment for degenerative diseases and genetic disorders. 
• Stem cell therapy can be used for a range of therapies from acute injuries to overall well-being, and many specialized treatments
• All our stem cell/MSC therapies are in-house tested and quality assured at point of care to ensure high quality treatments
• We offer cutting edge MSC-EV products, contact us for more information on MSC-EV therapy
• We will be offering CAR- t-cell therapy soon, contact us for more information

Mesenchymal stromal cell (MSC) therapy, also known as mesenchymal stem cell therapy, involves the use of MSCs for therapeutic purposes. Here are some basics about MSC therapy:

1. Definition and Characteristics: Mesenchymal stromal cells are a type of adult stem cells that can be isolated from various tissues, including bone marrow, adipose tissue (fat), umbilical cord tissue, and others. MSCs possess self-renewal capacity and the ability to differentiate into multiple cell types such as bone cells, cartilage cells, fat cells, and muscle cells.
2. Sources of MSCs: MSCs can be obtained from different tissue sources, each with its advantages and considerations. Common sources include:
   
   • Bone Marrow: Bone marrow aspiration is the traditional source of MSCs. It involves extracting MSCs from the bone marrow, typically from the hip bone (iliac crest) under anesthesia.
   • Adipose Tissue: MSCs can be harvested from adipose tissue through a minimally invasive procedure called liposuction. Adipose tissue is a rich source of MSCs, and the extraction process is generally well-tolerated.
   • Umbilical Cord Tissue: MSCs can be derived from the umbilical cord after the delivery of a newborn. Umbilical cord tissue is a non-invasive and readily available source of MSCs.

1. Potential Therapeutic Applications: MSCs have shown great therapeutic potential due to their unique properties. They can secrete various bioactive molecules and exhibit immunomodulatory, anti-inflammatory, and tissue repair properties. MSC therapy is being explored for various medical conditions, including:
   
   • Immune Disorders: MSCs have been investigated for their immunomodulatory effects in autoimmune diseases, graft-versus-host disease (GVHD), and organ transplantation.
   • Tissue Regeneration: MSCs have the capacity to differentiate into different cell types and contribute to tissue repair and regeneration. They have been studied for bone and cartilage regeneration, wound healing, and tissue engineering applications.
   • Neurological Disorders: MSCs have shown potential in promoting neuroprotection, reducing inflammation, and enhancing tissue repair in conditions such as stroke, spinal cord injury, and neurodegenerative diseases.
   • Cardiovascular Diseases: MSCs have been studied for their ability to promote angiogenesis (formation of new blood vessels) and tissue repair in cardiovascular conditions, such as myocardial infarction (heart attack) and heart failure.
   • Other Applications: MSC therapy is also being explored for conditions like liver diseases, lung diseases, diabetes, and more.

1. Delivery Methods: MSCs can be delivered to the patient's body through various routes, depending on the target condition and desired effects. Common delivery methods include intravenous (IV) infusion, local injection into the target site, or tissue engineering approaches using scaffolds or matrices to enhance tissue regeneration.
2. Safety Considerations: MSCs have shown a good safety profile in clinical studies, with minimal risk of immune rejection or adverse effects. However, further research is needed to ensure their safety and optimize their therapeutic use. Stringent quality control, characterization, and standardization of MSC products are crucial for clinical applications.

Literature on Mesenchymal stromal cell therapy and medicinal potential

There are many resources available on the web, a few research articles will be listed to help get directed about Mesenchymal stromal cells.

Links to recent literature:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365862/
 

https://www.nature.com/articles/nrd4738
 

https://www.nature.com/articles/npjregenmed20167 

Mesenchymal Stem Cells: Characteristics, Function,

 and Application - 2019

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431372/
 

https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01855-9 

CAR-t-cell therapy advances and treatments

https://www.mayoclinic.org/departments-centers/car-t-cell-therapy-program/sections/gnc-20405215

Health and Wellness

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CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) has witnessed significant advancements in recent years, enhancing its effectiveness and expanding its application. Here are some notable advancements in CAR T-cell therapy:

1. Targeting Multiple Antigens: Initially, CAR T-cell therapy focused on targeting a single antigen on cancer cells. However, researchers have made progress in developing CAR T cells that can recognize multiple antigens simultaneously. This approach can overcome antigen loss and increase the therapy's efficacy against cancer cells that may have heterogeneous antigen expression.
2. Off-the-Shelf CAR T Cells: One limitation of CAR T-cell therapy is the need to harvest and engineer patients' own T cells, which can be time-consuming and challenging for critically ill patients. Advances have been made in generating "off-the-shelf" CAR T cells using gene editing techniques like CRISPR/Cas9. These modified CAR T cells can be derived from healthy donors or cell lines, providing a readily available and standardized treatment option.
3. Combination Therapies: CAR T-cell therapy has been combined with other treatment modalities to enhance its efficacy. For example, combining CAR T-cell therapy with immune checkpoint inhibitors, such as PD-1 or CTLA-4 inhibitors, has shown synergistic effects by overcoming immunosuppression and improving CAR T-cell persistence and function.
4. Safety Enhancements: CAR T-cell therapy can lead to severe side effects, including cytokine release syndrome (CRS) and neurotoxicity. Researchers have been working on strategies to mitigate these toxicities. For instance, "switch" CAR T cells have been designed with controllable activation to minimize adverse effects. Additionally, the development of safer suicide genes allows for the elimination of CAR T cells if severe side effects occur.
5. Solid Tumor Applications: Initially, CAR T-cell therapy was primarily effective against blood cancers like leukemia and lymphoma. However, significant efforts have been made to extend CAR T-cell therapy to solid tumors. Various strategies, such as targeting tumor-specific antigens, improving CAR T-cell trafficking and persistence within solid tumors, and overcoming the immunosuppressive tumor microenvironment, are being explored to enhance the efficacy of CAR T-cell therapy against solid tumors.
6. Clinical Trials and Approvals: CAR T-cell therapy has gained substantial momentum, leading to the approval of several CAR T-cell therapies by regulatory authorities for specific indications. Ongoing clinical trials are evaluating the effectiveness of CAR T-cell therapy in various cancers and refining treatment protocols.

These advancements highlight the ongoing progress in CAR T-cell therapy, improving its efficacy, safety, and applicability to a broader range of cancers. Continuous research and clinical trials are expected to further refine and expand the utility of CAR T-cell therapy in the future.

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